ERK/MAPK-mediated alleviation in cognitive dysfunction in chronically stressed mice treated with ethyl acetate extracts of Cynomorium Songaricum

作者：Ma, S. Y.; Chang, H. S.; Cheng, D.; Zheng, J. C.; Tian, F. Z.; Li, L. L.; Li, X. J.; Lu, Y.^*

来源：Bulgarian Chemical Communications, 2017, 49: 178-183.

• Ethyl acetate
• Cynomorium songaricum (ECS)
• Cognitive function
• Chronic stress
• LTP
• MAPK
• Synaptic plasticity

This study explored the neuroprotective mechanism of ethyl acetate extracts of Cynomorium Songaricum Rup (ECS) in improving the cognitive dysfunction in chronically stressed mice. We tested the spatial learning and memory ability through water maze, the expression level of phosphorylated extracellular signal regulated kinase 1/2(P-Erk1/2) and phosphorylated cAMP response element protein (P-CREB) of mitogen-activated protein kinase (MAPK) signal pathway in the hippocampus. Besides, the expression of synaptophysin (Syn) and postsynaptic density protein 95 (PSD-95) was assessed. We also detected the long-term potentiation (LTP) by neurotic electrophysiology, observing the morphological change of hippocampal neurons by HE staining. The results showed that ECS could improve the learning and memory disorders caused by chronic stress in mice. This may be related to the raise in the expression of Syn and PSD-95 by activating the expression of P-Erk1/2 and P-CREB in MAPK signaling pathway.

• 出版日期2017
• 单位北京中医药大学