Antioxidants of therapeutic relevance in COPD from the neotropical blueberry Anthopterus wardii

作者：Flores Gema; Dastmalchi Keyvan; Dabo Abdoulaye J; Whalen Kathleen; Pedraza Penalosa Paola; Foronjy Robert F; D'Armiento Jeanine M; Kennelly Edward J^*

来源：Food Chemistry, 2012, 131(1): 119-125.

DOI：10.1016/j.foodchem.2011.08.044

• Anthopterus wardii
• Neotropical blueberry
• Flavone C-glycosides
• Superfruit
• ABTS
• IL-8
• MMP-1
• COPD

Four flavone C-glycosides, isoorientin (1), orientin (2), vitexin (3), and isovitexin (4), were isolated from the neotropical blueberry of Anthopterus wardii, a so-called "superfruit", using antioxidant activity-guided fractionation. A dose-response relationship of compounds 1-4 was determined for their anti-inflammatory activity against interleukin-8 (IL-8) and for the inhibition of matrix metalloproteinase-1 (MMP-1) expression, an inflammatory marker for chronic obstructive pulmonary disease. The four flavone C-glycosides exhibited inhibitory activity against IL-8 production and MMP-1 expression, with compounds 1, 3, and 4 having the most potent inhibitory activities in both assays at 100 mu g/ml. The structures of compounds 1-4 were determined by spectroscopic methods. These flavone C-glycosides are reported for the first time in the Anthopterus genus.

• 出版日期2012-3-1