Microbial transformation of oleanolic acid by Fusarium lini and -glucosidase inhibitory activity of its transformed products

作者：Choudhary M Iqbal^*; Batool Iffat; Khan Shamsun Nahar; Sultana Nighat; Shah S Adnan Ali; Atta Ur Rahman

来源：Natural Product Research, 2008, 22(6): 489-494.

DOI：10.1080/14786410601083787

• oleanolic acid
• microbial transformation
• fusarium lini
• enzyme inhibition
• alpha-glucosidase

The biotransformation of a pentacyclic triterpene, oleanolic acid (1), with Fusarium lini afforded two oxidative metabolites, 2,3-dihydroxyolean-12-en-28-oic acid (2), and 2,3,11-trihydroxyolean-12-en-28-oic acid (3). Metabolite 3 was found to be a new compound. The structures were characterized on the basis of spectroscopic studies. These metabolites exhibited a potent inhibition of -glucosidase enzyme.

• 出版日期2008