Anxiolytic-like effects of oleamide in group-housed and socially isolated mice

作者：Wei Xiu Yan; Yang Jing Yu; Dong Ying Xu; Wu Chun Fu^*

来源：Progress in Neuro-Psychopharmacology and Biological Psychiatry, 2007, 31(6): 1189-1195.

DOI：10.1016/j.pnpbp.2007.04.008

• anxiety
• elevated plus-maze test
• hole-board test
• light-dark test
• oleamide
• social isolation

Oleamide (cis-9,10-octadecenoamide) is an endogenous sleep-inducing lipid and prototypic member of a new class of biological signaling molecules identified in recent years. In the present study, the anxiolytic-like effect of oleamide was studied in several experimental models of anxiety in group-housed and socially isolated mice. As the results show, socially isolated mice exhibited an anxiogenic-like profile in the elevated plus-maze test, the light/dark test, and the hole-board test, which could be significantly reversed by oleamide (10 or 20 mg/kg, i.p.). Moreover, oleamide significantly reduced the anxiety levels in grouped-housed mice. In the isolation-induced aggressive test, oleamide markedly reduced the attacking duration and increased the attacking latency. It is concluded that oleamide has an anxiolytic-like effect in socially isolated or group-housed mice, which suggests that fatty acid amides might be involved in the regulation of anxiety-related behavior in mice.

• 出版日期2007-8-15
• 单位沈阳药科大学