Aminolysis-based surface modification of polyesters for biomedical applications

作者：Zhu, Yang^*; Mao, Zhengwei; Gao, Changyou

来源：RSC Advances, 2013, 3(8): 2509-2519.

DOI：10.1039/c2ra22358a

• HUMAN ENDOTHELIAL-CELLS
• SMOOTH-MUSCLE-CELLS
• POLY(L-LACTIC ACID)
• STEM-CELLS
• MODIFIED POLYCAPROLACTONE
• CHONDROITIN SULFATE
• PLASMA TREATMENT
• ADHESION
• DIFFERENTIATION
• IMMOBILIZATION

The ester-containing polymers, in particular polyesters, are widely used as biomedical materials due to their industrial availability and, in many cases, degradability. However, the commercially available polyesters are usually absent of bioactive sites or motifs to meet the requirements of some specific biomedical uses, especially in the field of tissue engineering and regenerative medicine. Aminolysis is a convenient and versatile method to introduce -NH2 or other functional groups onto the polyester surface. Functional moieties can then be conjugated to or grafted from these active sites. Numerous studies have managed to fabricate a series of functional surfaces on various types and forms of polyesters. They are capable of improving cell adhesion, proliferation and cellular functions, domination of stem cell differentiation and isolation of certain subgroup of cells, demonstrating the versatility of the aminolysis-based polyester surface modification in biomedical applications. The mechanism and kinetics of aminolysis reaction, as well as its subsequent influence on materials properties are discussed in this review. The successive functionalization strategies and derivative applications of the aminolyzed surfaces are introduced. Finally, the review concludes with current challenges and future perspectives.

• 出版日期2013
• 单位浙江大学