An efficient oxidative dearomatization-radical cyclization approach to symmetrically substituted bicyclic guttiferone natural products

作者：McGrath Nicholas A; Binner Joshua R; Markopoulos Georgios; Brichacek Matthew; Njardarson Jon T^*

来源：Chemical Communications, 2011, 47(1): 209-211.

DOI：10.1039/c0cc01419b

Detailed in this communication is an efficient synthetic approach towards the guttiferone family of natural products. Oxidatively unraveling a para-quinone monoketal followed by consecutive 5-exo radical cyclizations provides the bicyclic core. An additional strength of this approach is a late stage asymmetric desymmetrization of an advanced symmetric intermediate.

• 出版日期2011