An efficient method of chemical modification of BODIPY core

作者：Zatsikha Yuriy V; Yakubovskyi Viktor P; Shandura Mykola P; Dubey Igor Ya; Kovtun Yuriy P^*

来源：Tetrahedron, 2013, 69(10): 2233-2238.

DOI：10.1016/j.tet.2013.01.050

• BODIPY compounds
• Dyes/pigments
• UV/vis spectroscopy
• Fluorophores

A simple approach to the modification of BODIPY nucleus has been developed. The method is based on the reaction of acetaldehyde-substituted dye with primary amines followed by cyclization of enamine intermediates. This procedure allowed preparing a series of new BODIPY derivatives with functional substituents useful for various practical purposes, including bioconjugation and other biomedical applications. The synthesized BODIPYs annealed to a pyridone fragment are stable compounds and intense fluorophores with emission maximum around 615 nm. This lambda(em) may be red-shifted by the introduction of styryl substituent.

• 出版日期2013-3-11