Association of ABCG2 polymorphisms with ischemic stroke in a Chinese population

作者：Liu, Tonghanyu; Jiang, Feng; Liu, Xin; Zhang, Hongye; Wang, Lefeng; Liu, Wenzhi^*; Wang, Xingyu^*

来源：Annals of Human Genetics, 2018, 82(5): 325-330.

DOI：10.1111/ahg.12258

• ABCG(2)
• ischemic stroke
• SNPs

ATP-binding cassette, superfamily G, member 2 (ABCG(2)) has been shown to play an important role in the development of ischemic stroke in European and African American populations. The aim of the present study is to test the hypothesis that there are associations between ABCG(2) polymorphisms and ischemic stroke risk in a Chinese population. We conducted a case-control study including 967 participants with ischemic stroke and 939 stroke-free controls. The rs2231137C>T and rs2231142G>T were genotyped using a TaqMan real-time polymerase chain reaction assay. We found the rs2231137C>T and rs2231142G>T in ABCG(2) were significantly associated with ischemic stroke (sex-, age-, BMI-, SBP-, DBP-adjusted OR=1.252; 95% CI, 1.035-1.515; P-value=0.021 and OR=1.526; 95% CI, 1.085-2.146; P-value=0.015, respectively). By haplotype analyses, the haplotype T-G still had a strongly significant association with ischemic stroke (OR=0.806; 95% CI, 0.692-0.939; P-value=0.00568). Our findings identified the rs2231137C > T and rs2231142G> T polymorphisms of the ABCG(2) as risk factors for ischemic stroke in a Chinese population.

• 出版日期2018-9
• 单位大连大学; 首都医科大学