A 4-year retrospective study of add-on therapy to the fixed combination of dorzolamide/timolol for the treatment of POAG

作者：Hartleben Matkin Curt^*; Prada Diddier; Mancila Vences Rafael

来源：International Journal of Ophthalmology, 2014, 7(2): 330-334.

DOI：10.3980/j.issn.2222-3959.2014.02.25

• fixed combination
• Cosopt (R)
• dorzolamide/timolol
• prostaglandin analogs
• brimonidine
• glaucoma

AIM: To evaluate the long-term response to the fixed combination of dorzolamide/timolol in patients with primary open angle glaucoma (POAG) and the addition of other intraocular pressure (IOP) lowering medications such as prostaglandin analogs and brimonidine.
METHODS: A retrospective, non -randomized, and descriptive clinical study was performed with 182 eyes diagnosed with POAG. Patients were divided into three groups: a group with fixed combination of dorzolamide/timolol only, a second group with prostaglandin analogs plus fixed combination of dorzolamide/timolol, and a third group with the addition of brimonidine to the same fixed combination. IOP data were gathered retrospectively and the differences between groups were calculated.
RESULTS: IOP was reduced satisfactorily in all three groups; however, a progressive IOP reduction was noted in the group with the fixed combination plus prostaglandin analogs. In this group, a progressive, significant and more homogeneous response of the reduction was noted in comparison with the other groups.
CONCLUSION: IOP reduction was efficacious in all three groups. The addition of prostaglandin analogs showed progressive IOP reduction, progressive response and absence of long -term drift. Brimonidine did not show a significant additive effect.

• 出版日期2014-4-18