Administration of Prednisolone intravenously or Dexamethason orally in random donors reveals equal results in granulocyte collection: a single centre experience

作者：Kolovratova V; List J; Worel N; Jilma P; Leitner G^*

来源：Vox Sanguinis, 2012, 103(1): 75-78.

DOI：10.1111/j.1423-0410.2011.01567.x

• apheresis
• donors
• granulocyte concentrate
• granulocyte mobilization
• steroids

Since cytokine mobilization for granulocyte collections in random donors is not licensed in Austria, we investigated in a prospective analysis the effects of prednisolone or dexamethasone (DXM) in 153 donors (35 women/118 men) and in the collected products. Either prednisolone (50 mg) intravenously 4 h before granulocyte collection or DXM (8 mg) orally 12 h before collection was given. Collections were performed with the Cobe Spectra (CardianBCT, Lakewood). We recorded a significantly higher percentage of granulocytes in the peripheral blood of the DXM. However, the collected number of granulocytes was equal in both groups.

• 出版日期2012-7