科研之友
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摘要
Statins are a commonly prescribed cholesterol-lowering drug; however, it has recently been shown that they also have the beneficial side effect of enhancing bone matrix formation. As a result, this study is to assay probability effect of Pravastatin on osteogenesis which is made in experimental flaw and it is as a laboratory pattern in rat femur. This experimental study was conducted on 30 male SD rats. Animals were divided randomly into 3 groups (control and experimental). After induction of general anesthesia, a hole in size of 2 mm in diameter was made using a dental bit in femur width to medullary channel. After surgery, the control group received orally sterile water daily and experimental groups 1 and 2 respectively received daily 10 and 20 mg/kg/PO of Pravastatin. Histopathological and histomorphometrical studies for evaluation of bone healing were carried out in experimental rats, which were euthanized after 45 days of the experiment. In control group, defect seemed to be filled with woven bone and bone marrow spaces and in spite of a poor osteogenic activity. In experiment groups, many osteoblasts groupings, and young bone trabeculas increased in number and bone trabeculas more organized. Histomorphometric results, observed that Pravastatin has significant effect on bone healing in experimental groups 2 and 3 than control group (p=0/000), analyzing obtained results show that Pravastatin has significant effect in group 3 that received high dosage of Pravastatin than group 2 (p=0/000). The results of this study show that Pravastatin could stimulate osteogenesis in rats.
- 出版日期2013
