A PRACTICAL AND GREEN APPROACH TOWARD SYNTHESIS OF 2,4,5-TRISUBSTITUTED IMIDAZOLES WITHOUT ADDING CATALYST

作者：Wang, Min^*; Gao, Jingjing; Song, Zhiguo

来源：PREPARATIVE BIOCHEMISTRY & BIOTECHNOLOGY, 2010, 40(4): 347-353.

DOI：10.1080/10826068.2010.525418

• catalyzed by itself
• multicomponent reaction
• one-pot synthesis
• 2
• 4
• 5-trisubstituted imidazoles

A simple, efficient, and inexpensive procedure has been developed for the synthesis of 2,4,5-triaryl imidazoles by a three-component, one-pot condensation of benzil, aldehydes, and ammonium acetate in refluxing ethanol without adding catalyst. The ocatalyzed-by-itselfo approach shows a new direction in green synthesis of the title products.

• 出版日期2010
• 单位渤海大学