Advances in Pharmaceutical Strategies Enhancing the Efficiencies of Oral Colon-Targeted Delivery Systems in Inflammatory Bowel Disease.

作者：Guo Yilin^*; Zong Shiyu^*; Pu Yiqiong^*; Xu Benliang^*; Zhang Tong^*; Wang Bing^*

来源：Molecules, 2018, 23(7): 1622.

DOI：10.3390/molecules23071622

• inflammatory bowel disease
• targeted drug-delivery strategies
• treatment

Inflammatory bowel disease (IBD) is a common disease characterized by chronic inflammation in gastrointestinal tracts, which is primarily treated by administering anti-inflammatory and immunosuppressive drugs that inhibit the burden of intestinal inflammation and improve disease-related symptoms. However, the established therapeutic strategy has limited therapeutic efficacy and adverse drug reactions. Therefore, new disease-targeting drug-delivery strategies to develop more effective treatments are urgent. This review provides an overview of the drug-targeting strategies that can be used to treat IBD, and our recent attempts on the colon-specific delivery system (Pae-SME-CSC) with a paeonol-loaded self-microemulsion (Pae-SMEDDS) are introduced.

• 出版日期2018-7-4
• 单位上海中医药大学