NF-kappa B activation: nondegradative ubiquitination implicates NEMO

作者：Israel Alain^*

来源：Trends in Immunology, 2006, 27(9): 395-397.

DOI：10.1016/j.it.2006.07.003

Non-degradative ubiquitination events have been recently demonstrated to have an important role in activating the I kappa B kinase (IKK) complex, the central component of the nuclear factor (NF)-kappa B signaling cascade. Two new papers demonstrate that NF-kappa B essential modulator (NEMO)-IKK gamma, the structural and regulatory component of the IKK complex, specifically recognizes Lys63 polyubiquitin chains attached to the receptor-interacting protein (RIP)1 kinase following tumor necrosis factor treatment, and that this recognition is a requirement for IKK activation.

• 出版日期2006-9