Using Epigenetic Reprogramming to Treat Pediatric Brain Cancer

作者:Chheda Milan G; Gutmann David H*
来源:Cancer Cell, 2017, 31(5): 609-611.
DOI:10.1016/j.ccell.2017.04.008

摘要

In this issue of Cancer Cell, Nagaraja et al. dissect the molecular mechanisms underlying therapeutic responses to transcriptional disruptors in the fatal pediatric brain tumor, diffuse intrinsic pontine glioma (DIPG). Moreover, they identify super-enhancers mediating these effects, highlighting how normal brain developmental programs can be hijacked in cancer.

  • 出版日期2017-5-8