Association between hypertriglyceridemia and protein oxidation and proinflammatory markers in normocholesterolemic and hypercholesterolemic individuals

作者：Klafke Jonatas Zeni^*; Porto Fernando Garcez; Batista Roselaine; Bochi Guilherme Vargas; Moresco Rafael Noal; da Luz Protasio Lemos; Nazario Viecili Paulo Ricardo

来源：Clinica Chimica Acta, 2015, 448: 50-57.

DOI：10.1016/j.cca.2015.06.013

• Advanced oxidation protein products
• High-sensitivity C-reactive protein
• Ischemia-modified albumin
• Nitric oxide

Background: Although hypercholesterolemia is a well-established risk factor for coronary heart disease, evidence suggests that increased triglyceride (TG) concentrations are also an independent risk factor. TG concentrations >150 mg/dl are observed nearly twice as often in subjects with atherosclerosis. We assessed the association between hypertriglyceridemia and protein oxidation and proinflammatory markers in normocholesterolemic and hypercholesterolemic individuals.
Methods: We included 127 volunteers enrolled in Cruz Alta, RS, Brazil. The patients were stratified based on total cholesterol and TG concentrations for analysis of associations with inflammation (high-sensitivity C-reactive protein hs-CRP), endothelial dysnitric oxide NOx) and oxidative stress (advanced oxidation protein products AOPPs; ischemia-modified albumin IMA). Correlations between variables were determined and multiple regression analysis was employed to investigate whether some variables correlate with TG concentrations.
Results: Hypertriglyceridemia was related to oxidative stress and proinflammatory markers in individuals independent of total cholesterol concentrations. Moreover, the results indicate a stronger association of tested biomarkers with TG concentrations than with total cholesterol. The results indicate a positive correlation between oxidative stress and TG concentrations in the sera of hypercholesterolemia subjects. AOPPs and IMA concentrations were associated with the presence of hypertriglyceridemia in a manner that was independent of age, gender, hypertension and diabetes mellitus disease, smoking habits, sedentary lifestyle, BMI, waist circumference, LDL, HDL and total cholesterol concentrations.
Conclusions: We speculate that TG concentrations can reflect the enhancement of protein oxidation and proinflammation.

• 出版日期2015-8-25