A High Model for End-stage Liver Disease Score Should Not Be Considered a Contraindication to Living Donor Liver Transplantation

作者：Poon K S; Chen T H; Jeng L B^*; Yang H R; Li P C; Lee C C; Yeh C C; Lai H C; Su W P; Peng C Y; Chen Y F; Ho Y J; Tsai P P

来源：Transplantation Proceedings, 2012, 44(2): 316-319.

DOI：10.1016/j.transproceed.2012.02.006

Objective. To analyze the outcomes of patients with high Model for End-Stage Liver Disease (MELD) scores who underwent adult-to-adult live donor liver transplantation (A-A LDLT). %26lt;br%26gt;Materials and Methods. From September 2002 to October 2010, a total of 152 adult patients underwent A-A LDLT in our institution. Recipients were stratified into a low MELD score group (Group L; MELD score %26lt;= 30) and a high MELD score group (Group H; MELD score %26gt;30) to compare short-term and long-term outcomes. %26lt;br%26gt;Results. Of the 152 adult patients who underwent A-A LDLT, 9 were excluded from the analysis because they received ABO-incompatible grafts. Group H comprised 23 and Group L 120 patients. The median follow-up was 21.5 months (range, 3 to 102 m). The mean MELD score was 15.6 in Group L and 36.7 in Group H. There were no significant differences in the mean length of stay in the intensive care unit (Group L: 3.01 days vs Group H: 3.09 days, P = .932) or mean length of hospital stay (Group L: 17.89 days vs. Group H: 19.91 days, P = 0.409). There were no significant differences in 1-, 3-, or 5-year survivals between patients in Groups L versus H (91.5% vs 94.7%; 86.4% vs 94.7%; and 86.4% vs 94.7%; P = .3476, log rank). %26lt;br%26gt;Conclusion. The short-term and long-term outcomes of patients with high MELD scores who underwent A-A LDLT were similar to those of patients with low MELD scores. Therefore, we suggest that high MELD scores are not a contraindication to LDLT.

• 出版日期2012-3
• 单位中国医科大学