Diet and sex modify exercise and cardiac adaptation in the mouse

作者：Konhilas John P^*; Chen Hao; Luczak Elizabeth; Mckee Laurel A; Regan Jessica; Watson Peter A; Stauffer Brian L; Khalpey Zain I; Mckinsey Timothy A; Horn Todd; LaFleur Bonnie; Leinwand Leslie A

来源：American Journal of Physiology - Heart and Circulatory Physiology, 2015, 308(2): H135-H145.

DOI：10.1152/ajpheart.00532.2014

• cardiac hypertrophy
• sex and exercise
• diet
• soy

The heart adapts to exercise stimuli in a sex-dimorphic manner when mice are fed the traditional soy-based chow. Females undergo more voluntary exercise (4 wk) than males and exhibit more cardiac hypertrophy per kilometer run (18, 32). We have found that diet plays a critical role in cage wheel exercise and cardiac adaptation to the exercise stimulus in this sex dimorphism. Specifically, feeding male mice a casein-based, soy-free diet increases daily running distance over soy-fed counterparts to equal that of females. Moreover, casein-fed males have a greater capacity to increase their cardiac mass in response to exercise compared with soy-fed males. To further explore the biochemical mechanisms for these differences, we performed a candidate-based RT-PCR screen on genes previously implicated in diet-or exercise-based cardiac hypertrophy. Of the genes screened, many exhibit significant exercise, diet, or sex effects but only transforming growth factor-beta 1 shows a significant three-way interaction with no genes showing a two-way interaction. Finally, we show that the expression and activity of adenosine monophosphate-activated kinase-alpha 2 and acetyl-CoA carboxylase is dependent on exercise, diet, and sex.

• 出版日期2015-1-15