Stereocontrolled Synthesis of 5 '- and 6 '-Epimeric Analogues of Muraymycin Nucleoside Antibiotics

作者：Spork Anatol P; Ducho Christian^*

来源：Synlett, 2013, 24(3): 343-346.

DOI：10.1055/s-0032-1318117

• antibiotics
• medicinal chemistry
• natural products
• nucleosides
• biosynthesis

Naturally occurring nucleoside antibiotics, for example, Streptomyces-produced muraymycins, represent a promising class of potential lead structures for the development of novel antimicrobial agents. The efficient preparation of muraymycin analogues is an essential prerequisite for detailed structure-activity relationship (SAR) studies, particularly with respect to the variation of the stereochemistry in a controlled manner. In this work, stereoselective syntheses of 5'- as well as 6'-epimers of muraymycins are reported. The obtained target structures also represent useful probes for the elucidation of the biosynthesis of muraymycins and related nucleoside antibiotics.

• 出版日期2013-2