Duration of anaemia during the first week of life is an independent risk factor for retinopathy of prematurity

作者：Lundgren, Pia^*; Athikarisamy, Sam E.; Patole, Sanjay; Lam, Geoffrey C.; Smith, Lois E.; Simmer, Karen

来源：Acta Paediatrica, 2018, 107(5): 759-766.

DOI：10.1111/apa.14187

• Anaemia
• Blood transfusions
• Erythropoietin
• Preterm infants
• Retinopathy of prematurity

Aim: This study evaluated the correlation between retinopathy of prematurity (ROP), anaemia and blood transfusions in extremely preterm infants. @@@ Methods: We included 227 infants born below 28 weeks of gestation at King Edward Memorial Hospital, Perth, Australia, from 2014-2016. Birth characteristics and risk factors for ROP were retrieved, and anaemia and severe anaemia were defined as a haemoglobins of <110 g/L and <80 g/L, respectively. Logistic regression was used for the analysis. @@@ Results: Retinopathy of prematurity treatment was needed in 11% of cases and the mean number of blood transfusions (p<0.01), and mean number of weeks of anaemia (p<0.001) and of severe anaemia (p<0.05), had positive associations with ROP cases warranting treatment. In the multivariate logistic regression analysis, the best-fit model of risk factors included anaemic days during first week of life, with an odds ratio (OR) of 1.46% and 95% confidence interval (CI) of 1.16-1.83 (p<0.05), sepsis during the first 4 weeks of life (OR 3.14, 95% CI 1.10-9.00, p<0.05) and days of ventilation (OR 1.03, 95% CI 1.01-1.06, p<0.05). @@@ Conclusion: The duration of anaemia during the first week of life was an independent risk factor for ROP warranting treatment and preventing early anaemia may decrease this risk.

• 出版日期2018-5