A new approach to densely functionalised azepines and dihydroazepines

作者：Nedolya Nina A^*; Tarasova Ol'ga A; Albanov Alexander I; Volostnykh Ol'ga G; Brandsma Lambert; Trofimov Boris A

来源：Mendeleev Communications, 2008, 18(3): 164-166.

DOI：10.1016/j.mencom.2008.05.018

The easy transformation of 2-(1-alkoxyethoxy)-N-(1-methylethylidene)-1-(methylsulfanyl)-1,3-butadien-1-amines (2-aza-1,3,5-trienes) into 3-(1-alkoxyethoxy)-7-methyl-2-(methylsulfanyl)-4,5-dihydro-3H-azepines and 6-(1-alkoxyethoxy)-2-methyl-3H-azepines has been found to proceed under the action of Bu(t)OK in THF-DMSO or THF; the mild acidic hydrolysis of 4,5-dihydro-3H-azepines gives hydroxy derivatives.

• 出版日期2008-6