Proteomics of organelles and large cellular structures

作者:Yates JR*; Gilchrist A; Howell KE; Bergeron JJM
来源:Nature Reviews Molecular Cell Biology, 2005, 6(9): 702-714.
DOI:10.1038/nrm1711

摘要

The mass-spectrometry-based identification of proteins has created opportunities for the study of organelles, transport intermediates and large subcellular structures. Traditional cell-biology techniques are used to enrich these structures for proteomics analyses, and such analyses provide insights into the biology and functions of these structures. Here, we review the state-of-the-art proteomics techniques for the analysis of subcellular structures and discuss the biological insights that have been derived from such studies.

  • 出版日期2005-9