A short and straightforward approach towards 6-amino and 6-aminoalkyl thiazolo[4,5-c]pyridazines

作者：Stella Alessandro; De Jonghe Steven; Segers Kenneth; Herdewijn Piet^*

来源：Tetrahedron Letters, 2013, 54(8): 830-833.

DOI：10.1016/j.tetlet.2012.11.072

• Thiazolo[4,5-c]pyridazine
• Isothiocyanates
• Privileged structures
• Drug-like structures

A facile and efficient synthesis of 6-amino and 6-aminoalkyl thiazolo[4,5-c]pyridazines is reported. The key step for the construction of this novel bicyclic scaffold was the reaction between 3-amino-4-bromopyridazine derivatives and alkylisothiocyanates. The application of this methodology for the synthesis of a small library of thiazolo[4,5-c]pyridazines is also described.

• 出版日期2013-2
• 单位河北医科大学