Antidepressant Action on Mitochondrial Dysfunction in Psychiatric Disorders

作者：Adzic Miroslav; Brkic Zeljka; Bulajic Sonja; Mitic Milos; Radojcic Marija B

来源：Drug Development Research, 2016, 77(7): 400-406.

DOI：10.1002/ddr.21332

<jats:title>ABSTRACT</jats:title><jats:p>
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<jats:td>Preclinical Research</jats:td>
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</jats:table-wrap></jats:p><jats:p>Mitochondria are cell organelles crucial to the production of cellular energy. Several lines of evidence have indicated that mitochondrial dysfunction could be related to the pathophysiology of CNS diseases including bipolar disorder, major depressive disorder, and schizophrenia. These changes include impaired energy metabolism in the brain, co‐morbidity with mitochondrial diseases, the effects of psychotropics on mitochondrial function, increased mitochondrial DNA (mtDNA) deletion in the brain, and association with mtDNA polymorphisms. Additionally, psychotropic drug treatments can alter energy metabolism and may affect mitochondrial processes. This review focuses on recent findings regarding the effects of antidepressants on mitochondrial processes in psychiatric disorders. Drug Dev Res 77 : 400–406, 2016.

• 出版日期2016-11