Are presynaptic GABA-C rho 2 receptors involved in anti-nociception?

作者：Tadavarty R; Hwang J; Rajput P S; Soja P J; Kumar U; Sastry B R^*

来源：Neuroscience Letters, 2015, 606: 145-150.

DOI：10.1016/j.neulet.2015.08.049

• GABA-C receptors
• Spinal cord
• Pain
• Anti-nociception
• Substantia gelatinosa
• Dorsal horn

We investigated the anti-nociceptive effects of GABA-C receptors in the central nervous system. Intracisternal injection of CACA, a GABA-C receptor agonist or isoguvacine, a GABA-A receptor agonist, significantly increased the tail-withdrawal latency. TPMPA, a GABA-C receptor antagonist blocked the effects of CACA but not isoguvacine indicating that GABA-C receptors are involved in regulating pain. Further, double-labelled immunofluorescence studies revealed that GABA-C rho 2 receptors are expressed presynaptically in the spinal dorsal horn, especially, substantia gelatinosa, a region that has been previously implicated in analgesia by regulating nociceptive inflow. These data provide a provenance for future work looking at presynaptic spinal GABA-C receptors in the control of nociception.

• 出版日期2015-10-8