A Multicenter, Eight-Week Treatment, Single-Step Titration, Open-Label Study Assessing the Percentage of Korean Dyslipidemic Patients Achieving LDL Cholesterol Target with Atorvastatin Starting Doses of 10 mg, 20 mg and 40 mg

作者：Lee Cheol Whan; Baek Sang Hong; Hong Taek Jong; Choi Young Jin; Kim Young Jo; Ahn Tae Hoon; Ihm Sang Hyun; Bae Jang Ho; Hong Soon Jun; Kim Doo Il; Ahn Young Keun; Hur Seung Ho; Park Dae Gyun; Choi Dong Ju; Lee Seung Uk; Kim Bum Soo; Ryu Kyu Hyung; Jang Yang Soo; Lee Sang Hoon; Seung Ki Bae^*; Kim Hyo Soo

来源：Cardiovascular Drugs and Therapy, 2010, 24(2): 181-188.

DOI：10.1007/s10557-010-6225-0

• Atorvastatin
• Dyslipidemia
• Target goal achievement
• Flexible-starting dose

This study was designed to evaluate the safety and efficacy of algorithm-based atorvastatin therapy initiated at different starting doses of 10, 20, and 40 mg in Korean dyslipidemic patients.
Five hundred seventy-four patients were screened, and 425 were enrolled (low risk, n = 29; intermediate risk, n = 45; high risk, n = 351). The starting dose depended on a patient's cardiovascular risk and LDL-cholesterol (LDL-C) levels.
Of the patients, 253 (59.5%), 63 (14.8%) and 109 (25.6%) patients were assigned at baseline to 10 mg, 20 mg and 40 mg atorvastatin, respectively. 390 patients (91.8%) completed the study, and 35 discontinued prematurely. No patient in the low or intermediate risk groups was titrated to 80 mg at Week 4, whereas, 26 in the high risk group were. 81.9% of patients achieved their LDL-C target at Week 4, which was sustained through to Week 8 (86.0%). 89.1% of patients who were not titrated achieved their LDL-C target at Week 8, and 82.1% of patients who were titrated 1 step up achieved their LDL-C target at Week 8. Overall, about 40% reduction in LDL-C, non-HDL-C levels, and LDL-C/HDL-C ratio was observed during the follow-up. Triglyceride was reduced by similar to 10% by Week 8. HDL cholesterol was slightly increased over 8 weeks (2.6%). Atorvastatin was well tolerated at all dose levels.
Patient-tailored statin therapy according to an individual's risk category and LDL-C levels was safe and effective with a quick achievement of LDL-C target in Korean dyslipidemic patients.

• 出版日期2010-4