Nicotinic Receptors Containing the alpha 7 Subunit: A Model for Rational Drug Design

作者：Sharma G; Vijayaraghavan S^*

来源：Current Medicinal Chemistry, 2008, 15(28): 2921-2932.

DOI：10.2174/092986708786848703

The neuronal nicotinic receptor has gained considerable recognition as a target, not just for combating drug addiction but also for treating a number of illnesses ranging from neurodegenerative diseases to psychotic disorders like schizophrenia. This recognition has led to a burgeoning field examining the receptor at all levels. A class of nicotinic receptors that contains the alpha 7 gene product, apparently as a homomer, illustrates this multidisciplinary approach. Here, we review recent progress in our understanding of this class of receptors based on data from molecular, structural, physiological and patho-physiological studies. These studies have set the stage for rational drug design to combat disorders of the central nervous system. The studies also exemplify the cautious approach needed in developing CNS therapies and the importance of physiology in tempering drug design.

• 出版日期2008-12