A New Way to Accelerate the Distraction of the Transpalatal Suture in Growing Dogs Using Recombinant Human Bone Morphogenetic Protein-2

作者：Zhao Guiran; Wang Ying; Wang Guijun; Wang Chengyue; Yao Yusheng^*

来源：The Cleft Palate-Craniofacial Journal, 2017, 54(2): 193-201.

DOI：10.1597/15-044

• bone regeneration
• recombinant human bone morphogenetic protein-2
• transsutural distraction osteogenesis

Objective: The purpose of this study was to evaluate the administration of recombinant human bone morphogenetic protein-2 (rhBMP-2) on trans-sutural distraction osteogenesis (TSDO) of the transverse palatal suture in growing dogs.
Study Design: A total of 36 growing dogs were used in this study. The experimental animals were treated with different elastic force and rhBMP-2. The bone regeneration was determined with X-ray, histology, and clinical evaluation. The computed values underwent statistical analyses using analysis of variance.
Results: The maxillary complex was most noticeably advanced with an applied elastic force of 600 g (22.4 +/- 5.0 mm) and 800 g + rhBMP-2 (24 +/- 5.1 mm). Immunohistochemical staining showed that the expression of bone morphogenetic protein-2 and bone morphogenetic protein-4 varied with different elastic force. These changes were statistically significant when 600 g and 800 g + rhBMP-2 were applied within 2 weeks of distraction when compared with controls (P < .05).
Conclusions: The results of this study suggest that TSDO in the growing dog should be safe and well tolerated when inducing bony lengthening of the maxilla. rhBMP-2 plays an important role in bone regeneration using TSDO.

• 出版日期2017-3
• 单位锦州医科大学