Utility of ApoB/ApoA1 Ratio for the Prediction of Cardiovascular Risk in Children with Metabolic Syndrome

作者：Erdeve Senay Savas^*; Simsek Enver; Dallar Yildiz; Biyikli Zeynep

来源：Indian Journal of Pediatrics, 2010, 77(11): 1261-1265.

DOI：10.1007/s12098-010-0217-8

• Apolipoprotein AI
• Apolipoprotein B
• Apolipoprotein B/Apolipoprotein AI ratio
• Child
• Metabolic syndrome

To assess whether apoB/apoA1 ratio is associated or not with metabolic syndrome in obese children.
A 198 obese children and 41 healthy control subjects were enrolled in a cross-sectional study. The apoB/apoA1 ratio and other metabolic sydrome components in obese children with/without metabolic syndrome were compared to healthy controls.
The apoA1 level did not show significant difference (p = 0.664) but apoB level (p = 0.000) and apoB/apoA1 ratio (p = 0.001) were significantly higher in obese group than in control group. Also, the apoB/apoA1 ratio was significantly higher in obese children with metabolic syndrome when compared to obese children without metabolic syndrome (p = 0.007) and showed positive correlation with triglyceride (r = 0.404, p = 0.000) and negative correlation with high-density lipoprotein cholesterol (r = -0.593, p = 0.000).
The apoB/apoA1 ratio is associated with metabolic syndrome in obese children. An elevated apoB/apoA1 ratio may constitute an important feature of the metabolic syndrome. There is a need for long term follow-up studies concerning cardiovascular risk in obese children with metabolic syndrome and high apoB/apoA1 ratio.

• 出版日期2010-11