Association between cerebral metabolism and Rey-Osterrieth Complex Figure Test performance in Alzheimer's disease

作者：Melrose Rebecca J^*; Harwood Dylan; Khoo Theresa; Mandelkern Mark; Sultzer David L

来源：Journal of Clinical and Experimental Neuropsychology, 2013, 35(3): 246-258.

DOI：10.1080/13803395.2012.763113

• Alzheimer's disease
• ReyOsterrieth Complex Figure
• Fluorodeoxyglucose positron emission tomography
• Visuospatial
• Construction

The copy condition of the ReyOsterrieth Complex Figure (ROCF) is sensitive to Alzheimer's disease (AD) pathology, but its neural correlates remain unclear. We used fluorodeoxyglucose positron emission tomography (FDGPET) to elucidate this association in 77 patients with probable AD. We observed a correlation between ROCF and metabolic rate of bilateral temporalparietal cortex and occipital lobe, and right frontal lobe. Global and local elements of the ROCF correlated with metabolic rate of these same regions. The copy approach correlated with right lateral temporal cortex. The ROCF appears reflective of posterior temporalparietal cortex functioning, highlighting the role of visuospatial processing in constructional abilities in AD.

• 出版日期2013-3-1