Association of p53/p21 expression with cigarette smoking and prognosis in esophageal squamous cell carcinoma patients

作者：Taghavi Noushin; Biramijamal Firouzeh^*; Sotoudeh Masoud; Moaven Omeed; Khademi Hooman; Abbaszadegan Mohammad Reza; Malekzadeh Reza

来源：World Journal of Gastroenterology, 2010, 16(39): 4958-4967.

DOI：10.3748/wjg.v16.i39.4958

• Esophageal squamous cell carcinoma
• p53
• p21
• Immunohistochemistry
• Survival
• Smoking

AIM: To investigate the expression of p53 and p21 and associations with possible risk factors, such as cigarette smoking, in esophageal squamous cell carcinoma (ESCC) in northeastern Iran, a region with a high incidence of ESCC.
METHODS: The expression of p53 and p21 proteins was investigated immunohistochemically in tumor tissue from 80 ESCC patients and in 60 available paraffin-embedded blocks of adjacent normal specimens from the cases, along with normal esophageal tissue from 80 healthy subjects.
RESULTS: Positive expression of p53 protein was detected in 56.2% (45/80) of ESCC cases, and in none of the normal esophageal tissue of the control group (P < 0.001). Furthermore, 73.8% (59/80) of ESCC cases and 43.8% (35/80) of controls had positive expression of p21 protein (P < 0.001). Cigarette smoking was significantly associated with p53 over-expression in ESCC cases (P = 0.010, OR = 3.64; 95% CI: 1.32-10.02). p21 over-expression was associated with poorer clinical outcome among the ESCC patients (P = 0.009).
CONCLUSION: Over-expression of p53 in association with cigarette smoking may play a critical role in ESCC carcinogenesis among this high-risk population of northeastern Iran. Furthermore, p21 over-expression was found to be associated with poor prognosis, specifically in the operable ESCC patients.

• 出版日期2010-10-21