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摘要
A new approach for the facile chemodivergent synthesis of tetrahydroimidazo[1,2-a]pyridines from beta-ketothioamides, aldehydes and heterocyclic ketene aminals is described. In the presence of a base, an unprecedented ring-opening, tautomerization, recyclization cascade is observed and H2S eliminated tetrahydroimidazo[1,2-a]pyridines were formed in good yields. With catalytic amounts of acid, another type of different substituted tetrahydroimidazo[1,2-a]pyridines were obtained through dehydration.
- 出版日期2015
- 单位青岛科技大学
