An efficient four-component domino protocol for the rapid and green synthesis of functionalized benzo[a]pyrano[2,3-c]phenazine derivatives using caffeine as a homogeneous catalyst

作者：Abadi Afshin Yazdani Elah; Maghsoodlou Malek Taher^*; Heydari Reza; Mohebat Razieh

来源：Research on Chemical Intermediates, 2016, 42(2): 1227-1235.

DOI：10.1007/s11164-015-2083-5

• Multi-component reactions (MCRs)
• One-pot synthesis
• 1,3,7-Trimethylpurine-2,6-dione (caffeine)
• 2-Hydroxynaphthalene-1,4-dione
• o-Phenylenediamine
• Benzo[a]pyrano[2,3-c]phenazine

A one-pot, two-step procedure has been used to synthesize functionalized benzo[a]pyrano[2,3-c]phenazine derivatives from a four-component condensation reaction of 2-hydroxynaphthalene-1,4-dione, o-phenylenediamine, aldehydes, and malononitrile in the presence of 1,3,7-trimethylpurine-2,6-dione (caffeine) as an expedient and reusable solid base catalyst. This new procedure has the following advantages: operational simplicity, short reaction times, environmentally friendly, easy work-up, and all the products were obtained in excellent yields.

• 出版日期2016-2