Atom- and step-economic synthesis of biaryl-substituted furocoumarins, furoquinolones and furopyrimidines by multicomponent reactions and one-pot synthesis

作者：Kadam Asha; Bellinger Stephanie; Zhang Wei^*

来源：Green Processing and Synthesis, 2013, 2(5): 491-497.

DOI：10.1515/gps-2013-0064

• atom economy
• furocoumarin
• furopyrimidine
• furoquinolone
• multicomponent reaction
• one-pot synthesis
• step economy

Atom-efficient multicomponent reactions (MCR) and step-efficient one-pot synthesis are developed for the synthesis of biaryl-substituted furocoumarins, furoquinolones, and furopyrimidines. Furocoumarin and furoquinolone derivatives are synthesized by a three-component reaction, followed by the Suzuki coupling reaction. Furopyrimidine derivatives are prepared by the Suzuki coupling and then the three-component reaction. The bromobenzaldehydes are the key bifunctional molecules for the multicomponent and Suzuki coupling reactions.

• 出版日期2013-10