Association of the NFKBIA gene polymorphisms with susceptibility to autoimmune and inflammatory diseases: a meta-analysis

作者：Zhang, Guo-Long; Zou, Yan-Feng^*; Feng, Xiao-Liang; Shi, He-Jian; Du, Xu-Feng; Shao, Min-Hua; Gu, Yong; Zhou, Qing

来源：Inflammation Research, 2011, 60(1): 11-18.

DOI：10.1007/s00011-010-0216-2

• NFKBIA
• Genetic polymorphisms
• Autoimmune
• Inflammatory diseases
• Meta-analysis

Objective To quantitatively summarize the association of NFKBIA gene polymorphisms with autoimmune and inflammatory diseases. @@@ Methods We surveyed studies on the association of NFKBIA gene polymorphisms with autoimmune and inflammatory diseases in PubMed. Meta-analysis was performed in a fixed/random effect model. @@@ Results We identified 14 studies using a PubMed search. Meta-analysis was performed for NFKBIA gene polymorphisms at positions 2758 (A/G, 5 studies), -881 (A/G, 3 studies), -826 (C/T, 3 studies), and -297 (C/T, 3 studies). We did not detect associations of NFKBIA gene polymorphisms at positions 2758, -881, -297 with autoimmune and inflammatory diseases. An association of NFKBIA gene -826C/T polymorphism with autoimmune and inflammatory diseases was found (C vs. T: OR = 1.81, 95% CI = 0.97-3.36, P = 0.06; CT + TT vs. CC: OR = 2.11, 95% CI = 1.07-4.19, P = 0.03; TT vs. CC + CT: OR = 2.20, 95% CI = 0.78-6.21, P = 0.06; TT vs. CC: OR = 2.87, 95% CI = 0.78-10.62, P = 0.11; CT vs. CC: OR = 2.02, 95% CI = 1.22-3.36, P = 0.006). @@@ Conclusion This meta-analysis demonstrates that autoimmune and inflammatory diseases are associated with NFKBIA gene -826C/T polymorphism, but not with 2758A/G, -881A/G, and -279C/T.

• 出版日期2011-1
• 单位南京医科大学; 安徽医科大学