Pyrazinamide resistance determined by liquid culture at low pH better correlates with genetic mutations in MDR tuberculosis isolates

作者：Pang Yu^*; Wang Zhongdong; Zheng Huiwen; Song Yuanyuan; Wang Yufeng; Zhao Yanlin

来源：Journal of Microbiological Methods, 2015, 119: 142-144.

DOI：10.1016/j.mimet.2015.10.014

• Mycobacterium tuberculosis
• Pyrazinamide
• Drug resistance
• MGIT

We detected the pyrazinamide (PZA) susceptibility of Mycobacterium tuberculosis strains in the Bactec MGIT 960 liquid medium with different pH values. Our results demonstrated that PZA resistance determined by liquid culture at pH 5.7 (94.9%) showed better correlation with genetic changes among multidrug-resistant M. tuberculosis isolates (P = 0.001).

• 出版日期2015-12
• 单位山东省青岛市疾病预防控制中心; 中国疾病预防控制中心