Anterior chamber-associated immune deviation and its impact on corneal allograft survival

作者：Niederkorn Jerry Y^*

来源：Current Opinion in Organ Transplantation, 2006, 11(4): 360-365.

DOI：10.1097/01.mot.0000236697.07092.ac

• anterior chamber-associated immune deviation
• corneal transplantation
• immune privilege
• T-regulatory cells

Purpose of review <br xmlns:set="http://exslt.org/sets">Anterior chamber-associated immune deviation is a form of immune tolerance elicited by ocular antigens and corneal transplants. It produces antigen-specific downregulation of T-helper 1 immune responses and promotes corneal allograft survival. This review discusses recent insights in the induction of anterior chamber-associated immune deviation.
Recent findings
Although initial findings suggested that anterior chamber-associated immune deviation was a preferential activation of T-helper 2 immunity, recent findings indicate that T-helper 1 cytokines, such as interleukin-4 and interleukin-13, and T-helper 2 transcription factors are not needed. Findings indicate that ocular antigen-presenting cells migrate to the spleen and release antigenic peptides that are captured are reprocessed by splenic B cells, which present antigenic peptides to 1 cells on both major histocompatibility complex class I and class II molecules, leading to the generation of CD8(+) T-regulatory cells and CD4(+) T-regulatory cells.
Summary
Anterior chamber-associated immune deviation a complex immunoregulatory phenomenon involving multiple cell populations and four organ systems. Anterior chamber-associated immune deviation reduces the risk for immune-mediated inflammation in the eye and promotes corneal allograft survival. Understanding the mechanisms may help improve the survival of other organ transplants that are at risk for immune rejection.

• 出版日期2006-8