Always one step ahead: How pathogenic bacteria use the type III secretion system to manipulate the intestinal mucosal immune system

作者：Vossenkaemper Anna; MacDonald Thomas T; Marches Olivier

来源：Journal of Inflammation, 2011, 8: 11.

DOI：10.1186/1476-9255-8-11

• gut-associated lymphoid tissue type 3 secretion system
• EPEC
• Shigella

The intestinal immune system and the epithelium are the first line of defense in the gut. Constantly exposed to microorganisms from the environment, the gut has complex defense mechanisms to prevent infections, as well as regulatory pathways to tolerate commensal bacteria and food antigens. Intestinal pathogens have developed strategies to regulate intestinal immunity and inflammation in order to establish or prolong infection. The organisms that employ a type III secretion system use a molecular syringe to deliver effector proteins into the cytoplasm of host cells. These effectors target the host cell cytoskeleton, cell organelles and signaling pathways. This review addresses the multiple mechanisms by which the type III secretion system targets the intestinal immune response, with a special focus on pathogenic E. coli.

• 出版日期2011-5-3