A prospective analysis of smoking and human papillomavirus infection among men in the HPV in Men Study

作者：Schabath Matthew B^*; Villa Luisa L; Lin Hui Yi; Fulp William J; Lazcano Ponce Eduardo; Salmeron Jorge; Abrahamsen Martha E; Papenfuss Mary R; Quiterio Manuel; Giuliano Anna R

来源：International Journal of Cancer, 2014, 134(10): 2448-2457.

DOI：10.1002/ijc.28567

• HPV
• epidemiology
• incidence
• smoking

At present it is unknown whether the higher prevalence of human papillomavirus (HPV) infection among smokers in men is attributed to a higher probability of acquiring an infection or because of longer infection persistence. Thus, we investigated the role of smoking on the incidence (acquisition) and clearance (persistence) of genital HPV infections among 4,026 men in the HPV in Men (HIM) Study, a multinational prospective study of the natural history of genital HPV infection in men. Genital HPV infections were grouped by any, oncogenic and nononcogenic HPV infections and smoking status was categorized as current, former and never smokers. The incidence of any, oncogenic and nononcogenic HPV infections was significantly higher among current smokers compared to former and never smokers (p%26lt;0.01). In multivariable analyses adjusting for sexual behavior and potential confounders, when compared to never smokers, current smokers exhibited significantly higher probability of acquiring any [hazard ratio (HR)=1.23; 95% confidence interval (CI) 1.02-1.50] and nononcogenic (HR=1.21; 95% CI 1.00-1.45) infections and a borderline significant probability for oncogenic infections (HR=1.18; 95% CI 0.98-1.41). Although the median duration of HPV infection was generally longer among current smokers, we found no statistically significant associations in the multivariable analyses. Overall, these results demonstrated that current smoking exhibited the highest incidence and highest probability of acquiring genital HPV infections. %26lt;br%26gt;What%26apos;s new? Men who smoke are at increased risk of human papillomavirus (HPV) infection, though it is unclear whether that is because smoking influences the chances of acquiring HPV or the duration over which infection persists. This study, which focused on genital HPV infections in men, suggests that current smoking is associated with a high probability of acquiring a genital infection. Median duration of infection in current smokers was found to be longer than in former or never smokers, but the differences were not statistically significant.

• 出版日期2014-5-15