Glycosylation with N-acetyl glycosamine donors using catalytic iron(III) triflate: from microwave batch chemistry to a scalable continuous-flow process

作者：Xolin Amandine^*; Stevenin Arnaud; Pucheault Mathieu; Norsikian Stephanie; Boyer Francois Didier; Beau Jean Marie

来源：Organic Chemistry Frontiers, 2014, 1(8): 992-1000.

DOI：10.1039/c4qo00183d

Efficient and highly selective glycosylation reactions of peracetylated beta-D-N-acetyl gluco-and galactosamine are described using catalytic iron(III) triflate under microwave conditions or in a continuous flow process. Simple beta-glycosides and beta-(1 -> 6), beta-(1 -> 2) and beta-(1 -> 3) linked disaccharides bearing various protecting groups were obtained in high yields. Insights into the glycosylation mechanism are discussed.

• 出版日期2014