A model for the dynamics of mammalian family X DNA polymerases

作者：Xie, Ping^*

来源：Journal of Theoretical Biology, 2011, 277(1): 111-122.

DOI：10.1016/j.jtbi.2011.02.018

• DNA repair
• Polymerase beta
• Polymerase lambda
• Polymerase mu
• Terminal deoxynucleotidyl transferase

Based on available structural studies, a model is presented for polymerization dynamics of mammalian family X DNA polymerases, including polymerases b, lambda, mu, and terminal deoxynucleotidyl transferase (TdT). Using the model, distinct polymerization activities and processivities of the four polymerases acting on different forms of DNA substrate are analyzed and studied theoretically. A "gradient" of template dependence of polymerases b, lambda, mu, and TdT is well explained. The much higher occurrence frequencies of the -1 frameshift DNA synthesis by pols lambda and mu than that by pol beta are well explained. The theoretical results on the polymerization processivities are also in agreement with the available experimental data.

• 出版日期2011-5-21
• 单位中国科学院