Multiple phosphate-linked nucleotide couplings via 5 ' silyl ether protection in the phosphite triester and phosphoramidite approaches

作者：Bare Grant A L; Sherman John C^*

来源：Tetrahedron Letters, 2013, 54(24): 3207-3209.

DOI：10.1016/j.tetlet.2013.04.043

• Nucleotide
• Phosphoramidite
• Phosphite triester
• Template

Phosphite triester and phosphoramidite coupling methodologies are described for performing fourfold solution phase installations of standard deoxynucleotides onto a single cavitand template molecule. The methodologies here are based on 5' silyl ether protection of the appropriate nucleoside or nucleoside phosphoramidite. Synthesis of a novel water-soluble species incorporating four covalently-linked guanine nucleotides is shown.

• 出版日期2013-6-12