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摘要
Objectives: Acute kidney injury following cardiac surgery depicts a severe clinical problem that is strongly associated with adverse short-and long-term outcome. We analyzed two common genetic polymorphisms that have previously been linked to renal failure and inflammation, and have been supposed to be associated with cardiac surgery associated-acute kidney injury (CSA-AKI). Methods: A total of 1415 consecutive patients who underwent elective cardiac surgery with CPB at our institution were prospectively enrolled. Patients were genotyped for Apolipoprotein E (ApoE E2, E3, E4) (rs429358 and rs7412) and TNF-alpha-308 G>A (rs1800629). Results: Demographic characteristics and procedural data revealed no significant differences between genotypes. No association between ApoE (E2, E3, E4) and TNF-alpha-308 G>A genotypes and the RIFLE criteria could be detected. Several multiple linear regression analyses for postoperative creatinine increase revealed highly significant associations for aortic cross clamp time (p<0.001), CPB-time (p<0.001), norepinephrine (p<0.001), left ventricular p 0.004) and blood transfusion (p<0.001). No associations were found for ApoE (E2, E3, E4) and TNF-alpha-308 G>A genotypes or baseline creatinine. When the sample size is 1415, the multiple linear regression test of R 2 0 for seven covariates assuming normal distribution will have at least 99% power with significance level 0.05 to detect an R 2 of 0.108 or 0.107 as observed in the data. Conclusions: ApoE (E2, E3, E4) polymorphism and the TNF-alpha-308 G>A polymorphism are not associated with renal injury after CPB.
- 出版日期2014-3
- 单位河北医科大学
