Acute Transverse Myelitis and Acute Motor Axonal Neuropathy Developed after Vaccinations against Seasonal and 2009 A/H1N1 Influenza

作者：Sato Nozomu^*; Watanabe Kosuke; Ohta Kiyobumi; Tanaka Hiroaki

来源：Internal Medicine, 2011, 50(5): 503-507.

DOI：10.2169/internalmedicine.50.4340

• acute transverse myelitis
• acute motor axonal neuropathy
• post-vaccination
• influenza
• 2009 A/H1N1 influenza and interleukin-6

Acute transverse myelitis (ATM) has been described as an uncommon complication of vaccinations and is rarely accompanied by inflammatory peripheral neuropathy. We report a case of a 77-year-old woman who developed ATM and acute motor axonal neuropathy (AMAN) following vaccinations against seasonal and 2009 A/H1N1 influenza. She manifested ophthalmoplegia, quadriparesis and sensory impairment. MR imaging showed a longitudinally-extensive spinal cord lesion, and nerve conduction study revealed motor axonal polyneuropathy. Despite prompt treatment, her symptoms poorly recovered. While concurrent ATM and AMAN may suggest the presence of a common antigen, their scarcity indicates the importance of other factors causing immunologic disruptions.

• 出版日期2011