Anaphylaxis to succinylated gelatin in a patient with a meat allergy: galactose-alpha(1,3)-galactose (alpha-gal) as antigenic determinant

作者：Uyttebroek A; Sabato V; Bridts C H; De Clerck L S; Ebo D G^*

来源：Journal of Clinical Anesthesia, 2014, 26(7): 574-576.

DOI：10.1016/j.jclinane.2014.04.014

• Gelatin allergy
• Perioperative anaphylaxis
• alpha-gal allergy

Specific immunoglobulin E (sIgE) antibodies towards the galactose-alpha(1,3)-galactose (alpha-gal) moieties may elicit life-threatening and fatal anaphylactic reactions. Patients sensitized to alpha-gal moieties from mammalian meat may also react towards mammalian gelatins and gelatin-containing drugs such as bovine gelatin-based colloid plasma substitute. The case of a 56 year old woman with a meat allergy who suffered anaphylaxis to succinylated gelatin is reported.

• 出版日期2014-11