A systemic review of existing serological possibilities to diagnose canine osteoarthritis with a particular focus on extracellular matrix proteoglycans and protein

作者：Shahid M^*; Manchi G; Slunsky P; Naseer O; Fatima A; Leo B; Raila J

来源：Polish Journal of Veterinary Sciences, 2017, 20(1): 189-201.

DOI：10.1515/pjvs-2017-0024

• extra-cellular matrix
• canine osteoarthritis
• biomarker
• synovial fluid
• proteomix analysis

Extra-cellular matrix (ECM) components are important and their stabilization is significant in maintaining normal healthy joint environment. In osteoarthritis (OA), ECM components are altered and indicate disease progression. The joint ECM is composed of proteoglycans (aggrecan, perlecan, inter alpha-trypsin inhibitor), glycoproteins (fibronectin, lubricin, COMP) and collagen types (most abundantly collagen type II) which represent structural and functional transformation during disease advancement. ECM investigation revealed significant biomarkers of OA that could be used as a diagnostic and therapeutic tool in different canine orthopedic diseases. This review deliberates our current findings of how the components of ECM change at the molecular level during disease progression in canine OA.

• 出版日期2017
• 单位天津医科大学