New secondary metabolites produced by the phytopathogenic fungus Wilsonomyces carpophilus

作者：Narmani Abolfazl; Teponno Remy Bertrand; Arzanlou Mahdi; Babai Ahari Asadollah; Stadler Marc^*

来源：Phytochemistry Letters, 2018, 26: 212-217.

DOI：10.1016/j.phytol.2018.06.018

Two new metabolites possessing the unusual 1-oxa-7-azaspiro[4.4]non-2- ene-4,6-dione core (2, 3) along with the recently described pseurotin A(3) (1) were isolated from the pathogenic fungus Wilsonomyces carpophilus (previously named Stigmina carpophila). The producer organism was obtained from Prunus armeniaca collected in Iran and was identified by morphological and molecular phylogenetic methods. The structures of the isolated compounds were elucidated on the basis of extensive NMR spectroscopic analysis, high-resolution mass spectrometry and ECD analysis. The compounds were screened for their antimicrobial, cytotoxic, nematicidal and biofilm inhibition activities but, no significant effect was observed. To the best of our knowledge, this is the first report on the isolation of secondary metabolites produced by W. carpophilus.

• 出版日期2018-8