A VLSI Neural Monitoring System With Ultra-Wideband Telemetry for Awake Behaving Subjects

作者：Greenwald Elliot^*; Mollazadeh Mohsen; Hu Charles; Tang Wei; Culurciello Eugenio; Thakor Nitish V

来源：IEEE Transactions on Biomedical Circuits and Systems, 2011, 5(2): 112-119.

DOI：10.1109/TBCAS.2011.2141670

• Biopotential amplifier
• digital telemetry
• electrocorticogram
• electroencephalogram
• headmounted systems
• local field potentials
• micropower instrumentation
• neural interface
• ultra-wideband telemetry
• wireless neural recording

Long-term monitoring of neuronal activity in awake behaving subjects can provide fundamental information about brain dynamics for neuroscience and neuroengineering applications. Here, we present a miniature, lightweight, and low-power recording system for monitoring neural activity in awake behaving animals. The system integrates two custom designed very-large-scale integrated chips, a neural interface module fabricated in 0.5 mu m complementary metal-oxide semiconductor technology and an ultra-wideband transmitter module fabricated in a 0.5 mu m silicon-on-sapphire (SOS) technology. The system amplifies, filters, digitizes, and transmits 16 channels of neural data at a rate of 1 Mb/s. The entire system, which includes the VLSI circuits, a digital interface board, a battery, and a custom housing, is small and lightweight (24 g) and, thus, can be chronically mounted on small animals. The system consumes 4.8 mA and records continuously for up to 40 h powered by a 3.7-V, 200-mAh rechargeable lithium-ion battery. Experimental benchtop characterizations as well as in vivo multichannel neural recordings from awake behaving rats are presented here.

• 出版日期2011-4