An efficient, three-component synthesis and molecular structure of derivatives of 2-amino-3-R-6-ethyl-4,6-dihydropyrano[3,2-c][2,1] benzothiazine-5,5-dioxide spirocombined with a 2-oxindole nucleus

作者：Shemchuk Leonid A^*; Lega Dmitry A; Redkin Ruslan Gr; Chernykh Valentin P; Shishkin Oleg V; Shishkina Svetlana V

来源：Tetrahedron, 2014, 70(44): 8348-8353.

DOI：10.1016/j.tet.2014.09.005

• Benzo[c][2,1]thiazine
• 2-Oxindoles
• Methylene active nitriles
• Spirocyclic compounds
• 4,6-Dihydropyrano[3,2-c][2,1]benzothiazine-5,5-dioxide
• X-ray diffraction analysis

Spiro[(2-amino-3-R-6-ethyl-4,6-dihydropyrano[3,2-c][2,1]benzothiazine-5,5-dioxide)-4,3'-(1'-R'-5'-R ''-indolin-2'-one)] compounds were synthesized based on the three-component interaction of benzo[c][2,1]thiazin-4-on 2,2-dioxide with corresponding isatins and appropriate methylene active nitriles in the presence of a base as a catalyst. The molecular structures of the target compounds were proved uniquely by the X-ray diffraction analysis method.

• 出版日期2014-11-4