科研之友
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摘要
The organocatalytic asymmetric Michael addition of aldehydes to a nitro olefin in aqueous organic solvents catalysed by a broad range of simple primary amines and amino alcohols is reported. In particular, the use of (S,S)-diphenyl-ethylenediamine, which is the chiral backbone of various organocatalysts, gave addition products in good yields and with good to high enantioselectivities (45-96% ee). Remarkably high enantioselectivities were observed for the demanding conjugate addition of alpha,alpha-disubstituted aldehydes to nitrostyrene (96-98% ee) in aqueous organic solvent mixtures.
- 出版日期2015-9
